Stimulated Raman Spectroscopy and Microscopy with an All-Electronic Spectrometer
Provides built-in rejection of fluorescence that can mask the weaker Raman signals Achieves ultra-fast temporal sampling using time-division multiplexing (TDM) Achieves simultaneous fine spatial resolution Raman imaging and single-shot fine temporal resolution with the spatial localization inherent in nonlinear optical interactions Allows the study, direct probing, and potential control of molecular dynamics and chemical reactions
Detection of chemical compounds, biomolecules, and rare cell types (e.g., cancer cells) Single-shot study of chemical reactions without needing repetitive analysis Spatio-temporal Raman microscopy with sub-wavelength resolution Biochemical sensing with matched detection for efficient and effective bio-detectors Combinatorial chemistry synthesis with matched detection High-throughput detection and study of biological molecules and macromolecules (proteins, DNA, RNA, hormones, etc.), microbes, and pathogens (viruses, bacteria) Cancer screening and rare-cell detection without needing fluorescent dye preparation
The novel analysis method and apparatus can measure stimulated Raman scattering (SRS), coherent anti-stokes Raman scattering (CARS), and coherent Stokes Raman scattering (CSRS). It can analyze samples that are rapidly and irreversibly evolving, or destroyed by continuous exposure used in conventional techniques. Its extremely fast image acquisition times enable high throughput and can be used to directly monitor temporal dynamics of ultra-fast reactions, even capturing the Raman spectrum of a single molecule as it evolves.
Patent Number: US7821633B2
Application Number: US2008210656A
Inventor: Jalali, Bahram | Solli, Daniel | Chou, Jason
Priority Date: 28 Mar 2006
Priority Number: US7821633B2
Application Date: 15 Sep 2008
Publication Date: 26 Oct 2010
IPC Current: G01J000344
US Class: 356301 | 3560731
Assignee Applicant: The Regents of the University of California
Title: Apparatus and method for Raman spectroscopy and microscopy with time domain spectral analysis
Usefulness: Apparatus and method for Raman spectroscopy and microscopy with time domain spectral analysis
Summary: Used for performing stimulated Raman spectroscopy e.g. spontaneous Raman scattering, coherent anti-stokes Raman scattering and coherent stokes Raman scattering, of a sample such as biochemical molecule and rare cell type e.g. cancer cell, and also for acquiring spectral snapshots of the reaction at specific time intervals.
Novelty: Sample`s e.g. biochemical molecule, stimulated Raman spectroscopy e.g. coherent anti-stokes Raman scattering, performing method for acquiring spectral snapshot, involves exposing sample to beams of pulsed probe light
Disease Diagnostic/Treatment
Cancer/Tumor
7821633
Background Known analysis techniques, such as conventional repetitive-waveform probe spectroscopy, are unable to attain very high scan rates. This limits throughput and prevents molecular spectra measuring at any one moment in time. Thus, existing sample identification and cancer screening techniques are slow and have some margin of error. Furthermore, known optical spectrometers are physically bulky, which prevents their use in some applications. Additional Technologies by these Inventors Tech ID/UC Case 20147/2006-526-0 Related Cases 2006-526-0
USA
