Synthetic Bone Grafts
Bioengineers from UC San Diego have developed a hydrogel-based mineralization process to synthesize porous mineralized bone mimetic material. By varying pendant side-chain lengths to control matrix hydrophobicity, the inventors developed a means to regulate the nucleation of aptatite-like phases on a polymeric substrate.This technology can be used to develop mineral-polymer composite materials for use as scaffolds in bone tissue engineering and as bone grafts, as well as in other applications requiring the templated synthesis of organic/inorganic composite materials.
Patent Number: US8709452B2
Application Number: US13549045A
Inventor: Varghese, Shyni | Phadke, Ameya
Priority Date: 15 Jul 2011
Priority Number: US8709452B2
Application Date: 13 Jul 2012
Publication Date: 29 Apr 2014
IPC Current: A61K000900 | A01N006300 | A61K004700 | A61K004732
US Class: 424400 | 4240937 | 5147724 | 5147726 | 514781 | 514788
Assignee Applicant: The Regents of the University of California
Title: Synthetic bone grafts
Usefulness: Synthetic bone grafts
Summary: The composition is useful for treating a bone disease or disorder and for growing bone tissue (all claimed). No biological data given.
Novelty: Composition, useful for treating a bone disease or disorder and for growing bone tissue, comprises a hydrogel modified with amino acids having an anionic pendant side chain
Biomedical
Rehabilitation
State Of Development Results from biocompatibility experiments suggests that the material is highly promising as a bone graft. A patent application has been filed. Additional detailed information is available under a secrecy agreement. Related Materials Tech ID/UC Case 22465/2011-007-0 Related Cases 2011-007-0
USA
