A Restriction Spectrum Imaging Method and Device for Probing Tissue Microstructure
The device and method: Are able to non-invasively measure both the dimension (scale) and orientation (geometry) of separable hindered and restricted water compartments.Capture important microstructural information that is not afforded by traditional DSI or HARDI.Can be implemented on most current clinical MRI systems using modest scan times (5 to 10 minutes).
The technology may be used to develop non-invasive biomarkers of healthy and diseased tissue and may be customize to enable the measurement of such biomarkers.
UC San Diego researchers have developed an advanced diffusion MRI method, which can be used to probe tissue orientation structures over a range (or "spectrum") of hindered and restricted diffusion length scales with minimal assumptions on the underlying microarchitecture. The invention uses a linear mixture model to relate biological tissue parameters to diffusion MRI signals, which may be collected with various combinations of diffusion gradient strengths, diffusion times, diffusion weighting factors ("b-values"), and diffusion directions. An efficient estimation procedure is used to remove unwanted contributions to the measured signal, while preserving the desired signals related to the tissue parameters of interest.
Inventor: White, Keith David
Priority Number: US7863896B2
IPC Current: G01V000300
US Class: 324309 | 324317
Assignee Applicant: University of Florida Research Foundation Inc.inesville
Title: Systems and methods for calibrating functional magnetic resonance imaging of living tissue
Usefulness: Systems and methods for calibrating functional magnetic resonance imaging of living tissue
Summary: For calibrating function MRI for diagnosing e.g. patients brain.
Novelty: Method of calibrating function MRI for diagnosing patients brain, involves obtaining data sets from tissue using imaging instrument to determine figure of merit of imaging instrument, contrast simulation device and tissue
Biomedical
Medical Imaging
9404986
State Of Development Histological examination of tissue samples has been used to validate a method that can probe tissue orientation structures over a range of length scales with minimal assumptions about the underlying microarchitecture. In addition, the method has been shown to capture important, structural information that is not afforded by traditional DSI or HARDI.Software implemented in related Case 2012-844 (copyright). Intellectual Property Info Pending US rights available for exclusive licensure. Related Materials Additional Technologies by these Inventors Tech ID/UC Case 22214/2011-311-0 Related Cases 2011-311-0, 2012-844-1
USA
