Methods of Using Porous Silicon Nano/Micro-Particles for Time-Gated Fluorescence Imaging
UC San Diego researchers have developed porous silicon nanoparticles (pSiNP) that can emit visible to near-IR light under photoexcitation, have long luminescence lifetimes (> 10 nanoseconds) and optionally contain quenching/stabilizing molecules that can adjust the luminescence lifetime and intensity from the nanoparticle. The invention also provides methods to fabricate said pSiNP and of time gating the emission of the pSiNP to enable higher fidelity imaging by eliminating background signals (e.g., tissue autofluorescence, spectral bleed through). In contrast to many nanomaterials, pSiNP degrade into renally cleared components in a relatively short period of time with little or no evidence of systemic or cellular toxicity. Moreover, due to their porous nature, the nanoparticles can carry additional species such as drugs, smaller nanoparticles, fluorescence sensitizers or fluorescence quenching agents.
Inventor: SAILOR, Michael, J. | GU, Luo | HALL, David, J. | MATTREY, Robert
Priority Number: WO2012149312A1
IPC Current: G01N002164 | G01N003352
Assignee Applicant: The Regents of the University of California
Title: TIME-GATED FLUORESCENCE IMAGING WITH SI-CONTAINING PARTICLES | IMAGERIE PAR FLUORESCENCE RÉSOLUE DANS LE TEMPS À PARTICULES CONTENANT DU SI
Usefulness: TIME-GATED FLUORESCENCE IMAGING WITH SI-CONTAINING PARTICLES | IMAGERIE PAR FLUORESCENCE RÉSOLUE DANS LE TEMPS À PARTICULES CONTENANT DU SI
Summary: For time-gated fluorescence imaging and tissue (e.g. tumor, brain, cardiac, skin) monitoring; and imaging leverages the fluorescence lifetime of a fluorescent Si-containing particle to distinguish from background fluorescence.
Novelty: Time-gated fluorescence imaging and tissue monitoring involves introducing fluorescent silicon-containing particle into tissue, applying excitation light pulse, and time-gated measuring of responsive luminescence signal to identify particle
Disease Diagnostic/Treatment
Cancer/Tumor
2014015184
Intellectual Property Info The invention has a patent pending and is available for licensing and/or sponsorship. Tech ID/UC Case 22212/2011-306-0 Related Cases 2011-306-0
USA
