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High Throughput Protein 3D Structure Determination Employing Enhanced Amide Deuterium Exchange Mass Spectrometry (DXMS)

Technology Application

This technology is especially adapted to utilize data acquired and processed by existing high-throughput instrumentation, chemistries, and software ("DXMS") recently developed at UC San Diego.

Detailed Technology Description

UC San Diego researchers have invented a technique for high-resolution 3D protein structure determination that breaks through the limitations presented by crystallographic and NMR-based techniques. The method uses rapidly acquired, high-resolution amide deuterium exchange-mass spectrometric (DXMS) experimental data that has been obtained from microgram quantities of soluble protein in order to provide constraints sufficient to determine a protein's high-resolution 3D structure.

Industry

Biomedical

Sub Group

DNA/Gene Engineering

Others

Intellectual Property Info

See U.S. patent application number 10/577,179.

Tech ID/UC Case

22001/2003-105-0

Related Cases

2003-105-0, 2002-108-0, 2002-157-0, 2003-107-0

Country/Region

USA

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