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Biodegradable Luminescent Porous Silicon Nanoparticles for In Vivo Applications

Detailed Technology Description

UC San Diego researchers have developed luminescent porous silicon nanoparticles (LPSiNP) that can carry a drug payload and whose intrinsic near-infrared photoluminescence allows in-vivo monitoring of accumulation and degradation. Unlike most optically active nanomaterials (e.g., carbon nanotubes, gold nanoparticles, quantum dots), LPSiNP self-destruct into renally cleared components relatively quickly with little evidence of toxicity. The invention also provides imaging agents (e.g., tumor imaging using dextran-coated LPSiNP). It presents a new type of multifunctional nanostructure with a low-toxicity degradation pathway for in vivo applications.

Supplementary Information

Patent Number: US20110300222A1
Application Number: US13202271A
Inventor: Sailor, Michael J. | Gu, Luo | Park, Ji-Ho
Priority Date: 20 Feb 2009
Priority Number: US20110300222A1
Application Date: 18 Aug 2011
Publication Date: 8 Dec 2011
IPC Current: A61K000916 | A61K000900 | A61K004700 | B32B000516 | C01B003312 | C12Q000102 | B82Y000500 | B82Y004000
US Class: 424493 | 423335 | 424400 | 424490 | 428402 | 435029 | 514770 | 977700 | 977895 | 977927
Assignee Applicant: The Regents of the University of California
Title: LUMINESCENT POROUS SILICON NANOPARTICLES, METHODS OF MAKING AND USING SAME
Usefulness: LUMINESCENT POROUS SILICON NANOPARTICLES, METHODS OF MAKING AND USING SAME
Summary: Biodegradable porous nanostructure used as biodegradable imaging agent or used for preparing pharmaceutical composition (claimed).
Novelty: Biodegradable porous nanostructure used as biodegradable imaging agent or used for preparing pharmaceutical composition, comprises silicon material and having predetermined emission spectra and excitation spectra

Industry

Chemical/Material

Sub Group

Nano Materials

Others

Related Materials

Park, J.-H.; Gu, L.; Maltzahn, G. v.; Ruoslahti, E.; Bhatia, S. N.; Sailor, M. J., "Biodegradable Luminescent Porous Silicon Nanoparticles for In Vivo Applications." Nature Mater. 2009, 8, 331-336.
Safer Nanoparticles SpotlightTumors, Deliver Drugs, see the following two links:
http://ucsdnews.ucsd.edu/newsrel/science/02-09safenano.asp
http://ucsdnews.ucsd.edu/video/safenano.html
NSF Discovery: Safer Nano Cancer Detector

Intellectual Property Info

This invention has patent pending and is available for sponsored research and/or licensing.

Tech ID/UC Case

20975/2009-246-0

Related Cases

2009-246-0

Country/Region

USA

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