Antibodies targeting mammalian Sterol Regulatory Element Binding Proteins (SREBP) 1 and 2
§ The developed antibodies have high affinity and specificity for SREBP 1 and 2, relative to commercially available reagents § High utility as a research tool to identify transcriptional targets § Potential robust immunotherapeutic
SREBP 1 and 2 are important regulators of fatty acid and cholesterol metabolism, respectively. While these proteins are known to play a significant role in lipid homeostasis, there is still much to be learned about their physiological targets, both related to lipid biosynthesis and other pathways. Recently, UCI researchers identified 426 targets of just SREBP-1. These researchers have prepared antibodies to fragments of SREBP 1 and 2 that have greater affinity and specificity than current commercially available reagents. These novel antibodies are highly desirable tools for studying SREBP in culture and animal models. Furthermore, SREBP antibodies may also be promising immunotherapeutics in metabolic diseases.
State Of Development In vivo studies in mouse model Related Materials Tech ID/UC Case 27241/2015-862-0 Related Cases 2015-862-0
USA
