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Monoclonal Antibody Against CEP164 (Clone 13)

Technology Benefits

Specific antibody to detect Cep164 by antibody-antigen complex formation.

Technology Application

Immunocytochemistry/immunofluorescence Immunoprecipitation Western blot

Detailed Technology Description

Centrosomal protein 164kDa (Cep164) is involved in a number of cellular pathways. It is important for microtubule organization and maintenance for the formation of primary cilia. Additionally, Cep164 is critical for G2/M checkpoint and nuclear divisions. Cep164 is also involved in DNA damage-activated ATR/ATM signaling through proper phosphorylation of H2AX, RPA, CHK2, and CHK1. Furthermore, by modulating MDC1, RPA, and CHK1, Cep164 is a mediator that maintains genomic stability critical for chromosomal segregation. The described mouse monoclonal IgG1 antibody binds to human Cep164 and has been described for use in immunocytochemistry/immunofluorescnece, immunoprecipitation, and western blot.

Others

Related Materials

Cep164 is a mediator protein required for the maintenance of genomic stability through modulation of MDC1, RPA, and CHK1.

Additional Technologies by these Inventors

Tech ID/UC Case

25195/2011-388-0

Related Cases

2011-388-0, 2011-086-0, 2011-375-0, 2011-376-0, 2011-377-0, 2011-378-0, 2011-379-0, 2011-380-0, 2011-381-0, 2011-382-0, 2011-383-0, 2011-384-0, 2011-385-0, 2011-386-0, 2011-387-0

Country/Region

USA

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