Imaging Method for Improved Placement of MIGS

This invention is more quantitative than the episcleral venous pressure method The procedure can be done prior to the surgery to determine if a patient is a good candidate for MIGS procedure. Patients who do not have outflow pathway amenable to MIGS procedures will be spared the expense, time, and recovery of surgery. Cost-saving due to optimization of existing surgical techniques and screening for the patients most likely to respond to the surgeries. This present invention is also significantly less invasive and more clinically translatable compared to other methods.

Researchers in UC Irvine’s Opthalmology department have established an ex-vivo system to image episcleral vessels and quantify the regional blood flow. Successfully identifying the collector channels in the trabecular meshwork (TM) may be crucial to achieve an effective MIGS. The previous studies that have been successfully imaged the TM outflow anatomy required excessive tissue processing which limited the clinical applicability. The present invention utilized the confocal laser microendoscope to image both surface episcleral vessels and Schlemm’s canal through a scleral flap in ex vivo perfused eyes. Combining the microendoscope imaging and image analysis by using an algorithm, the episcleral vessel diameter and density could be acquired in real-time. Researchers have successfully imaged episcleral vessels using this method in both human cadaver eyes and pig eyes. Future Development Plans The next development step is to perform the MIGS procedures based on the functional data obtained with this invention and see if targeting MIGS procedures to high flow (or low flow) area can lower intraocular pressure. We are currently looking for a commercial partner to further develop this invention.

20160262606

Tech ID/UC Case

24885/2015-325-0

Related Cases

2015-325-0

USA