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Sphingolipid Drugs Triggering Nutrient Transporter Down-Regulation

Technology Application

These compounds may be developed for cancer therapies employing a novel mechanism of starving malignant cells. Specifically, these compounds could be useful for the treatment of certain blood-borne cancers and leukemias.

Detailed Technology Description

UCI researchers have designed and synthesized novel compounds that do not necessarily involve Fingolimod's S1P receptor-related, dose limiting toxicities. Specifically, the UCI researchers have designed a family of Azacyclic constrained analogs that overcome the dose-limiting toxicities of Fingolimod and down-regulate cellular nutrient transport. Studies in a mouse model suggest that these compounds do not exhibit undesirable cardio-vascular effects or sequester lymphocytes like Fingolimod.

Application No.

2016015973

Others

Tech ID/UC Case

23535/2013-802-0

Related Cases

2013-802-0, 2016-031-0

Country/Region

USA

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