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Directed Evolution Of AAV Vectors That Undergo Retrograde Axonal Transport

Technology Benefits

AAV can be endowed with robust retrograde functionality through directed evolution Up to two orders of magnitude increase in retrograde transport over existing variants Efficiency comparable to synthetic tracers in many circuits Payload expression levels are sufficient for circuit interrogation and gene manipulation

Technology Application

Gene therapy, including the treatment of neurodegenerative disorders characterized by pathological spread through functionally connected and highly distributed networks.

Detailed Technology Description

None

Application No.

WO2017218842

Others

Additional Technologies by these Inventors

Tech ID/UC Case

25943/2016-193-0

Related Cases

2016-193-0

Country/Region

USA

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