Structure-Guided Methods Of Cas9-Mediated Genome Engineering

Genetic engineering or editing of Cas9 polypeptides Controlling of site-specific gene regulation

None

Publication

Structures of Cas9 endonucleases reveal RNA-mediated conformational activation 

Additional Technologies by these Inventors

• Compositions and Methods of Use for Variant Csy4 Endoribonucleases
• Methods and Compositions for Controlling Gene Expression by RNA Processing
• Methods and Compositions for Using Argonaute to Modify a Single-Stranded Target Nucleic Acid
• Efficient Site-Specific Integration Of New Genetic Information Into Human Cells
• Cas9 Variants With Altered DNA Cleaving Activity
• Split-Cas9 For Regulatable Genome Engineering
• Single-Stranded Nucleic Acid Detection And Imaging System Using Cas9
• Methods For High Signal-To-Noise Imaging Of Chromosomal Loci In Cells Using Fluorescent Cas9
• Identification Of Sites For Internal Insertions Into Cas9
• Cas13a/C2c2 - A Dual Function Programmable RNA Endoribonuclease
• Small Molecule Assisted Cell Penetrating Cas9 RNP Delivery
• THERMOSTABLE RNA-GUIDED ENDONUCLEASES AND METHODS OF USE THEREOF (GeoCas9)
• Cas12c/C2C3 Compositions and Methods of Use
• A Dual-RNA Guided CasZ Gene Editing Technology
• Endoribonucleases For Rna Detection And Analysis

Tech ID/UC Case

23719/2014-078-0

Related Cases

2014-078-0

USA