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Non-Thermal Irreversible Electroporation And Immune System Enabled Tissue Engineering

Technology Benefits

Process can carry out the cell removal in the absence of any chemicals, toxins or enzymes typically used to in order to eliminate the cells.No need for immunosuppressant drugsReduced risk of graph rejectionECM rich in cell signaling components essential for cell adhesion, migration, proliferation and differentiationECM has a greater resistance to infection as compared to synthetic materials

Technology Application

Methods of treatment (e.g, tissue repair or regeneration)Non-thermal irreversible electroporation

Detailed Technology Description

None

Supplementary Information

Patent Number: US20120226218A1
Application Number: US13391577A
Inventor: Phillips, Mary | Maor, Elad | Rubinsky, Boris | Lavee, Jacob
Priority Date: 4 Sep 2009
Priority Number: US20120226218A1
Application Date: 27 Apr 2012
Publication Date: 6 Sep 2012
IPC Current: A61M003700 | A61K003512 | A61K003522 | A61K003534 | A61K003538 | A61K003542
US Class: 604020 | 424520 | 424551 | 424557 | 424558 | 424569
Title: EXTRACELLULAR MATRIX MATERIAL CREATED USING NON-THERMAL IRREVERSIBLE ELECTROPORATION
Usefulness: EXTRACELLULAR MATRIX MATERIAL CREATED USING NON-THERMAL IRREVERSIBLE ELECTROPORATION
Summary: The extracellular matrix is useful: for a treatment in a mammal (human); in cosmetic surgery; for repair of a body part; and for treating damaged tissue, which is used in cosmetic surgery and to kill cells in a target area of tissue, the tissue of an organ is a blood vessel, a heart, a lung, an intestine, and a bladder. The NTIRE is useful to kill cells on a segment of a human blood vessel for use in transplantation to repair another vessel in the same human and live cells are endothelial cells (all claimed). Test details are described but no results given.
Novelty: Extracellular matrix produced by subjecting target area of tissue to non-thermal irreversible electroporation, allowing mammal's immune system to remove killed cells and extracting target area, used e.g. to treat damaged tissue