Novel Approach For Identifying Bioactive Ligands For Use In Semi-interpenetrating Polymer Networks (sipns)
Can use highly sensitive fluorescence-based sensors of cellular signaling.
Novel approaches to identify bioactive ligands.
None
Patent Number: US8501905B2
Application Number: US2009532098A
Inventor: Schaffer, David V. | Healy, Kevin Edward | Little, Lauren | Daugherty, Patrick Sean
Priority Date: 22 Mar 2007
Priority Number: US8501905B2
Application Date: 18 Mar 2010
Publication Date: 6 Aug 2013
IPC Current: C07K000200 | C07K000500
US Class: 530300 | 530327
Assignee Applicant: The Regents of the University of California
Title: Synthetic cell platforms and methods of use thereof
Usefulness: Synthetic cell platforms and methods of use thereof
Summary: The methods are useful for identifying a peptide that binds a cell surface molecule present on a mammalian stem cell surface, identifying a peptide that activates a cell signaling pathway in a mammalian stem cell, culturing a mammalian stem cell in vitro, isolating a desired cell type or cell population, enhancing survival of a cell implanted into a recipient individual, inducing in vivo differentiation of a stem cell implanted into a recipient individual, for promoting recruitment of a cell to a site in an individual (all claimed). The cells and composition are useful for treating cancer (e.g. a leukemia), AIDS, sickle cell anemia, immune disorder (e.g. acquired immunodeficiency or genetic immunodeficiency), Type 1 diabetes, nervous system disorder (e.g. Alzheimer's disease, Parkinson's disease, Huntington's disease, Lou Gehrig's disease, spinal cord injury, or stroke), liver disorder (e.g. hepatitis, cirrhosis, a metabolic disorder affecting the liver or CNS), a disorder of the cartilage or bone (e.g. osteoarthritis or osteoporosis), cardiac disorder (myocardial infarction, coronary artery disease, or other disorder resulting in ischemic cardiac tissue), renal disorders (e.g. kidney failure), skeletal muscle disorders (e.g. muscular dystrophy), or lung disorder (e.g. emphysema, pulmonary fibrosis, or idiopathic pulmonary fibrosis).
Novelty: Identifying a peptide that binds a cell surface molecule comprises contacting a mammalian stem cell with bacterial cells displaying on its cell surface a different synthetic peptide
Disease Diagnostic/Treatment
Cancer/Tumor
8501905
Related Technologies Tech ID/UC Case 17824/2007-103-0 Related Cases 2007-103-0
USA
