Real-time, Single Step Bioassay With Ultra-high Sensitivity
Fast detection and diagnosis of complex diseasesFaster patient recovery Less testing via multiplexed measurements
Early stage cancer detectionBioassayForensic investigation -seminal droplets
None
Patent Number: US20110058164A1
Application Number: US2010772118A
Inventor: Zhang, Xiang | Ellman, Jonathan A. | Chen, Fanqing Frank | Sun, Cheng | Su, Kai-Hang | Wei, Qi-Huo
Priority Date: 2 Nov 2007
Priority Number: US20110058164A1
Application Date: 30 Apr 2010
Publication Date: 10 Mar 2011
IPC Current: G01J000344
US Class: 356301
Assignee Applicant: The Regents of the University of California
Title: Time resolved single-step protease activity quantification using nanoplasmonic resonator (NPR) sensor
Usefulness: Time resolved single-step protease activity quantification using nanoplasmonic resonator (NPR) sensor
Summary: As nanoplasmonic resonator (NPR) in nanoplasmonic resonance surface enhanced Raman scattering detection platform; for in vitro detection and measurement of enzymatic activity using a nanosensor; for real-time reaction monitoring of enzyme activity; for detecting the activity of multiple enzymes simultaneously (claimed); for enzymatic activity measurement used in drug screening, diagnosis and disease staging and molecular profiling; and also for detection of protease activity such as prostate specific antigen (PSA) and proteolytically active prostate specific antigen for diagnostic application in prostate cancer.
Novelty: Nanoplasmonic resonator used e.g. for in vitro detection and measurement of enzymatic activity comprises metallic nanodisks with alternating shielding layers having tagged biomolecule conjugated or tethered to the surface of the resonator
Disease Diagnostic/Treatment
Cancer/Tumor
8685743
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