Engineering Enhanced Retroviral Vectors Through The Insertion Of A His6 Tag Into Vsv-g
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Patent Number: US8163893B2
Application Number: US2008279171A
Inventor: Schaffer, David V. | Yu, Julie H.
Priority Date: 15 Feb 2006
Priority Number: US8163893B2
Application Date: 5 Feb 2009
Publication Date: 24 Apr 2012
IPC Current: C07H002104 | C12N001500 | A01N006300
US Class: 5360234 | 4353201 | 53602372
Assignee Applicant: The Regents of the University of California
Title: Pseudotyped retroviral vectors and methods of use thereof
Usefulness: Pseudotyped retroviral vectors and methods of use thereof
Summary: For production of a pseudotyped retroviral vector; useful for delivering a gene product into an individual (claimed), useful for encoding proteins for the treatment of endocrine, metabolic, hematologic, cardiovascular, neurologic, musculoskeletal, urologic, pulmonary and immune disorders; including inflammatory diseases, autoimmune, chronic and infectious diseases; such as acquired immunodeficiency syndrome (AIDS), cancer, hypercholesterolemia, insulin disorders such as diabetes, growth disorders, various blood disorders including various anemias, thalassemias and hemophilia; genetic defects such as cystic fibrosis, Gaucher's disease, Hurler's Disease, adenosine deaminase (ADA) deficiency, and emphysema.
Novelty: New nucleic acid for production of pseudotyped retroviral vector for delivering gene product comprises nucleotide sequence encoding recombinant viral envelope protein that comprises rhabdovirus envelope protein and heterologous polypeptide
Disease Diagnostic/Treatment
Cancer/Tumor
8163893
Tech ID/UC Case 17317/2004-010-0 Related Cases 2004-010-0
USA
