***SOFTWARE DISCOSURE***** The Vfold RNA Folding Package
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- *Abstract
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Value PropositionVfold is a software package that predicts the folding free energies, structures and stability of Ribonucleic acid (RNA). Better predictions can help scientists researching RNA-based therapeutics. Discoveries in this field could create new treatment options for most human diseases and disorders (About RNA Therapeutics, 2011). Many pharmaceutical companies are investing and developing RNA-based solutions. AVI Bio Pharma recently announced successful Phase I clinical testing for an RNA based therapy for the Ebola virus - an often fatal, and previously untreatable disease (AVI BioPharma's RNA-Based Therapeutics for Treatment of Ebola and Marburg Viruses Show Positive Safety Data in First Five of Six Cohorts of Phase 1 Clinical Studies , 2011). This burgeoning market will require robust predictive software, such as the Vfold package. Brief Description of TechnologyThe structures and stabilities of RNAs relate to their biological function and biomedical applications. Vfold is a software package for the computational prediction of RNA structure and stability from nucleotide sequences. Several competing factors determine RNA structural formation (folding) and the stability. The stacking force between the nucleotide bases and the change of conformational entropy upon folding are some examples. Vfold uses a three-vector virtual bond RNA mode to compute the conformation entropy. Based on the conformational entropy, the model predicts the free energy, structure and stability.Licensing OpportunitiesFor those interested in licensing, business partnerships, or more information on this technology, contact Wayne McDaniel at the Office of Technology Management & Industry Relations for more details.InventorsShie-Jie Chen, Ph.D.Song Cao, Ph.D.Peinan Zhao, Ph.D.FieldsRNA therapeuticsKey Features• Better efficacyStage of DevelopmentSoftware fully developed
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Name: Shi-Jie Chen
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Name: Song Cao
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- USA
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