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Tests for Polycystic Kidney Disease in Domestic Cats

Technology Benefits

Non-invasive, lower cost DNA methods for diagnosis; Carrier detection at time of birth; Small required amount of DNA for testing; and, More informed breeding decisions.

Technology Application

Polycystic kidney disease test in companion animal species (such as domestic cats)Development of better drug and gene therapies for polycystic kidney disease

Detailed Technology Description

DNA mutation tests for polycystic kidney disease in domestic cats have been developed by University of California, Davis researchers. Currently, polycycstic kidney disease affects approximately 40% of the Persian cat population. In addition, this disease has spread to other breeds, and is the most prominent inherited feline disease. Onset of the polycycstic kidney disease is variable and high cost ultrasound techniques are not 100% accurate and require additional visits to veterinarian specialists for diagnosis. Using direct DNA sequencing, University investigators have identified a causative mutation in the feline PKD1 gene allowing for early detection of this dominant disease.

Supplementary Information

Patent Number: US7141376B2
Application Number: US2004857260A
Inventor: Lyons, Leslie A. | Grahn, Robert A. | Erdman, Carolyn A.
Priority Date: 28 May 2004
Priority Number: US7141376B2
Application Date: 28 May 2004
Publication Date: 28 Nov 2006
IPC Current: C12Q000168 | C07K001447 | C12P001934 | C07H002102 | C07K000100 | C07K001600 | C12N000121 | C12N001563 | C12P002106 | G01N0033536
US Class: 43500613 | 435006 | 4350691 | 4350912 | 43525233 | 4353201 | 436536 | 530350 | 5303871 | 5360231
Title: Carrier tests for polycystic kidney disease in the cat
Usefulness: Carrier tests for polycystic kidney disease in the cat
Summary: The polynucleotide is useful for detecting mutations associated with polycystic kidney disease in the cat.
Novelty: New polynucleotide, i.e. polycystic kidney disease 1 (PKD1), useful for detecting mutations associated with polycystic kidney disease in the cat