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Test for Hereditary Equine Regional Dermal Asthenia (HERDA)

Technology Benefits

UC Davis researchers have developed a test which breeders could use to screen their breeding stock for carriers, to reduce or eliminate the possibility of producing affected horses.

Technology Application

This test provides both a means of diagnosing the disease prior to clinical signs as well as a means for breeders to avoid producing affected animals.

Detailed Technology Description

Hereditary Equine Regional Dermal Asthenia (HERDA) is an inherited skin disease found in the American Quarter Horse population. There is no treatment for the disease and the severe lesions associated with HERDA most often result in the euthanasia of affected horses. Researchers at the University of California, Davis have developed a test for identifying carriers of HERDA. Furthermore, this test can detect affected animals prior to clinical signs. Homozygosity mapping was used to isolate the locus. Microsatellites and gene-based single nucleotide polymorphism (SNP) markers were used to reduce the critical interval around the disease locus to a small region, predicted to contain 20 known genes and approximately 2.0-2.5 MB of DNA based on comparisons with other mammalian genomes. A SNP within the coding region of one of the genes within this critical interval was discovered within the affected HERDA population and can be used as an informative marker for identifying unaffected carriers of the disease.

Supplementary Information

Patent Number: US7608400B2
Application Number: US2007787611A
Inventor: Bannasch, Danika | Tryon, Robert | White, Stephen
Priority Date: 18 Sep 2006
Priority Number: US7608400B2
Application Date: 16 Apr 2007
Publication Date: 27 Oct 2009
IPC Current: C12Q000168 | C12P001934
US Class: 43500611 | 435006 | 43500612 | 4350911 | 4350912
Assignee Applicant: The Regents of the University of California
Title: Methods for detecting a cyclophilin B SNP associated with HERDA
Usefulness: Methods for detecting a cyclophilin B SNP associated with HERDA
Summary: The method and kit are useful for detecting a single nucleotide polymorphism associated with hereditary equine regional dermal asthenia phenotype in an equine (all claimed).