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Multiplexed Point-of-Care Breast Cancer Marker Detection System

Technology Benefits

Less wait time Cost effective Disposable Higher accuracy

Technology Application

Automated, point-of-care protein array-based immunoassay device capable of sensitive, simultaneous detection of multiple breast cancer markers Multiplex immunoassay technology for point-of-care diagnostic applications

Detailed Technology Description

The presence and advancement of tumors has been shown to be associated with the expression of certain molecular markers. However, currently no single ideal marker exists for breast cancer. Researchers at the University of California, Davis and the Lawrence Livermore National Laboratory (LLNL) have developed a multiplexed immunoassay to measure a panel of five related molecular markers to achieve more relevant and reliable information for diagnosis of breast cancer. Compared to current breast cancer detection methods, which are associated with long wait times, high costs, skilled labor, physical and psychological trauma and low accuracy, UC Davis and LLNL researchers have developed a rapid, cost effective, disposable, sensitive microarray based device capable of detecting the multiplexed panel of markers. In addition, UC Davis and LLNL researchers are also modeling the interaction of antigen and antibody in this type of an immunoassay and the effect of flow on the reaction rates in this device.

Supplementary Information

Patent Number: US20080200342A1
Application Number: US200831625A
Inventor: Rao, Rupa S. | Lane, Stephen M. | Matthews, Dennis L. | Coleman, Matthew A.
Priority Date: 15 Feb 2007
Priority Number: US20080200342A1
Application Date: 14 Feb 2008
Publication Date: 21 Aug 2008
IPC Current: C40B003004 | C40B003000 | C40B006012
US Class: 506009 | 506007 | 506039
Title: Device, Array, And Methods For Disease Detection And Analysis
Usefulness: Device, Array, And Methods For Disease Detection And Analysis
Summary: The device is useful for determining the presence or absence of biomarkers in a sample (claimed). It can also be used for scoring a sample for diagnosing a disease.
Novelty: New detection device comprises solid support, vertical support, and absorbent material, useful for determining the presence or absence of biomarkers in a sample and for scoring a sample for diagnosing a disease

Industry

Chemical/Material

Sub Group

Chemical/Material Application

Application No.

9366668

Others

Tech ID/UC Case

11222/2005-529-0

Related Cases

2005-529-0

Country/Region

USA

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