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Gd(III)-Dithiolane Gold Nanoparticle Conjugates for MRI of the Pancreas

Technology Benefits

Capability to post-modify any gold nanoparticle with a Gd(III) contrastingagent for MRI application Improved spatial and temporal resolution than PET, bioluminescence, CT,and ultrasoundExtremely high Gd(lll} chelate loading on the particles surface Variability of synthesized formsStraightforward conjugation procedure Applicable to other shapes of gold nanoparticles, including goldnanostars.Capability to form complexes with other relevant biological metals (e.g., radionuclides99mTc (SPECT}, 64Cu, 68Ga (PET)) with fast metalation kinetics and highthermodynamic stability constants, in addition to fast particle binding

Detailed Technology Description

A lipoic acid functionalized Gd(III)-gold nanoparticleconjugate as a MRI contrast.#diagnostics #nanoparticles #therapeutics #imaging#theranostics

Country/Region

USA

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