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Engineering Induced Pluripotent Stem Cells for COPD Therapy

Summary

Researchers at Oklahoma State havedeveloped a method that can induce 90% differentiation of iPSCs or MSCs intoAECs (type II) under stimulation of proper growth factors and growing on anappropriate matrix. These cells expressed type II cell markers surfactantprotein C and ABCA3, secrete lung surfactant in response to lung surfactantsecretagogues and trans-differentiate into type I AECs. Inaddition, the researchers have demonstrated that the AEC cells attenuated lung injuryin a mouse model of COPD. The potential uses for these cells includecellular-based therapies, drug screening, disease modeling and pulmonary research.

Technology Benefits

· 90% differentiation efficiency of iPSCs or MSCs into AECs

Technology Application

· Therapeutic for pulmonary diseases, including COPD· Drug discovery· Disease modeling· Pulmonary research· Stem cell research

Detailed Technology Description

None

Country/Region

USA

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