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Neuropiln 1 (Nrp1) Modulation for Immune System Control (SJ-13-0012)
Detailed Technology Description
Description Boosting the ability of regulatory T cells by blocking an effective anti-tumor immune response led to the elimination or dramatic reduction of melanoma by the immune system in mice, without causing the autoimmune and inflammatory problems often associated with current cancer-treatment efforts that target immune regulators. The mechanism is built around two proteins. One, semaphorin-4a (Sema4a), is carried on the surface of various immune cells that can spark inflammation. The other, neuropilin-1 (Nrp1), is carried on the surface of regulatory T cells.
Country/Region
USA
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