Synthetic vesicles for orthopedic and dental mineralization

Repairing bone and dental injuries is challenging for orthopedic and oral surgeons. In cases in which significant portions of the bone or tooth has been destroyed, grafted tissue can be used to repair the defect. However, tissues repaired using grafts are often weaker than the original tissue. The repaired tissue can be strengthened through remineralization, the process of depositing synthetic minerals, such as hydroxyapatite, at the site of repair, but this process has yet to be perfected. Because synthetic minerals must be deposited at the time of surgery but are required throughout the healing process, they are often deposited at very high, non-physiological concentrations. In turn, these high concentrations can actually impede the healing process. This technology provides a method to deliver vital remineralization compounds via synthetic vesicles that release minerals gradually over time, resulting in the deposition of physiologically normal levels of calcium chloride, sodium phosphate and betaglycerophosphate, which may speed and improve the repair of damaged bone and dental tissue.

Vesicle-based delivery method mimics natural healing processesLow-concentration, extended release vesicles decrease both the amount of material used and the potential for tissue toxicity at the site of deliveryLocal, targeted vesicle-based delivery can improve both the duration and extent of healing, resulting in stronger dental and orthopedic repairs in a shorter timePatent information:Patent Pending Tech Ventures Reference: CU12195

Improved dental cement for dental repair surgeriesImproved bone cement for orthopedic surgeriesImproved orthopedic/dental implant coatingImproved orthopedic/dental repair scaffoldingBiomimetic drug deliveryVesicle-based delivery of nucleic acid-based therapiesVesicle-based delivery of growth factors and other healing compounds

None

USA