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Small-molecule Malaria treatment and prevention strategy

Summary

Malaria has created a global health crisis that affects 500 million people worldwide each year. The parasite that causes malaria, Plasmodium falciparum, is adaptive and readily develops drug resistance. Therefore, there is a pressing need to develop new treatments as existing treatments become increasingly obsolete. This technology is a library of small-molecules that inhibit a target protein, Equilibrative Nucleoside Transporter 1 (PfENT1), preventing the parasite's proliferation. These compounds provide a strategy for developing new malaria treatments and preventative therapeutics.

Technology Benefits

PfENT1 is a drug target for the malaria parasite, P. falciparumPatent Information:Patent Pending (WO/2014/210319)Tech Ventures Reference: IR CU13311

Technology Application

Potential drug treatment for malaria and cerebral malariaPotential prophylaxis for malariaPotential drug target for other parasitic diseasesBasic research on PfENT1 inhibition

Detailed Technology Description

None

Country/Region

USA

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