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Small molecule inhibitor for more precise biotin/streptavidin tagging affords improved live cell imaging

Summary

Milan Stojanovic, Ph.D.

Technology Benefits

Significantly faster and cheaper method to produce monovalent streptavidin than other strategiesHighly compatible with nearly all commercially-available labeled or modified streptavidinImproves spatial resolution allowing usage in super resolution imaging methodsOligonucleotide backbone can be fully customizedInteractions with oligonucleotide backbone act as conditional switch that can free up one binding siteInhibitor itself can be tagged or labeled, if desiredPatent information:Patent Pending (WO/2013/036826Tech Ventures Reference: IR 2927

Technology Application

Improves biotin labeling for live-cell imaging by blocking crosslinkingCreates simple one-to-one biotin/streptavidin complex which simplifies analysisAllows biotin labeling to be used for direct counting quantificationImprovement of a biotin immobilization strategySensitive detection of RNA or DNABlock strategy can also be used to make smaller inhibitor that produces divalent streptavidin

Detailed Technology Description

Milan Stojanovic, Ph.D.

Country/Region

USA

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