AsiaIPEX is a one-stop-shop for players in the IP industry, facilitating IP trade and connection to the IP world. Whether you are a patent owner interested in selling your IP, or a manufacturer looking to buy technologies to upgrade your operation, you will find the portal a useful resource.

Back to search results

Second harmonic generation for measuring the relative orientation in a pair of DNA-binding molecules

Summary

Kenneth Eisenthal, Ph.D.

Technology Benefits

Measures drug-induced DNA unwinding.Acquires data in solution more closely mimicking the DNA environment in vivo.Improves research and development of new DNA-binding drug candidates.Patent information:Patent Pending (US/2012/0202296)Tech Ventures Reference: IR CU13153

Technology Application

Screen the effects of DNA-binding compounds on DNA unwinding.Probe basic structural features of biochemical complexes for the study of structural biology.Provide information on other potential structural changes induced by drug binding distinct from DNA unwinding, such as kinking or supercoiling.Use as a general DNA binding assay if SHG intensity reproducibly changes when a compound binds to DNA.

Detailed Technology Description

Kenneth Eisenthal, Ph.D.

Country/Region

USA

For more information, please click Here