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PCR assay detects mutant genes with 50 to 100-fold increase in sensitivity

Technology Benefits

• Requires relatively simple modifications to current PCR processes.• Detects mutant alleles present in very low concentrations.• Sensitivity increase of 50-100 fold.Patent information:US 61/561,703

Technology Application

• Amplify small quantities of known mutations in the presence of large amounts of the wild-type allele.• Highly sensitive detection of mutations in breast cancer, and potentially other solid tumors such as colon and pancreatic. • Diagnostic test for personalized cancer therapy.• Detecting micro-metastases.• Forensic applications (identifying small amounts of a specific DNA sequence).

Detailed Technology Description

Increasing the sensitivity for detection of mutations in cancer cells through modified PCRPolymerase chain reaction (PCR) involves separation of double stranded DNA and sequential amplification of target genes in order to detect gene sequ...

Country/Region

USA

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