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Photoactivated, localized drug delivery utilizing visible and infrared light

Summary

Light is a powerful pharmacological tool that can be used to selectively activate a photo-reactive drug in a specific location. This method, called photodynamic therapy, has been used successfully as a treatment for a variety of cancers including lung, pancreatic, esophageal, and skin cancers. However, most current photodynamic therapies require ultra-violet light, which has poor tissue penetration depths and can severely damage cells. This technology is a class of ruthenium-based tethers that can bind compounds and release them when exposed to visible or infrared light. It can be used to deliver a variety of biologically active molecules, including neurotransmitters, locally and selectively.

Technology Benefits

Visible and infrared light pose no risk to biological tissuesVisible and infrared light sources are inexpensive when compared to ultraviolet light sourcesAllows for precise control over drug deliveryCan be adapted for a wide range of drug-tether complexesPatent Information:Patent Pending (US 20120116287)Patent Pending (US 20080176940)Patent Pending (WO/2005/065192)Tech Ventures Reference: IR M09-102

Technology Application

Selective release of chemotherapeutic agentsSelective release of neurotransmittersSelective delivery of a variety of bioactive compounds Basic research tool for imaging and cell labeling

Detailed Technology Description

None

Country/Region

USA

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