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A novel method to inhibit growth of Varicella Zoster Virus

Technology Benefits

Provides a novel and effective method to control or inhibit infection/reactivation of the VZV virus for treating and preventing chicken pox and shinglesProvides an attractive alternative to the chicken pox vaccine (which has a poor rate of disease prevention) to alleviate the symptoms and lessen the severity of chicken pox/shinglesProvides a potential therapeutic method for other viral diseases such as outbreaks of HSV, which is highly homologous to VZV and shares a similar method of activation

Technology Application

Provides an antibiotic effective to inhibit replication of VZV in a host cellProvides an siRNA effective to inhibit VZV in a host cellProvides an assay to screen for candidates that inhibit VZV replication by quantitating the change in a chaperone protein activity Provides novel anti-viral mechanism for developing therapies against other viral infections such as HSV

Detailed Technology Description

This invention identified a novel anti-viral mechanism that is important for developing novel combination therapy, using VZV infection as an example. Infection and reactivation of VZV requires the transport of a viral protein ORF29p from the cytoplas...

Country/Region

USA

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