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Rapid, high-resolution, and depth-resolved non-invasive optical tissue imaging

Technology Benefits

Imaging at high frame-rate Can image up to depths greater than 2 mm 100-200 micron resolution Multi-wavelength imaging of absorption, fluorescence and flow contrast Imaging and simultaneous measurements of living dynamic systems Can generate 3D (depth-resolved) images of surveyed region

Technology Application

Clinical imaging (diagnostic/evaluative, treatment response) Hillman E. M. C, Bernus O, Pease E, Bouchard M. B. Pertsov A. "Depth-resolved optical imaging of transmural electrical propagation in perfused heart", Optics Express, 15 (26), 17827-17841, 2007.Hillman E. M. C, Devor A, Bouchard M. B, Dunn A. K, Krauss GW, Skoch J, Bacskai J, Dale A. M, Boas D. A. "Depth-resolved Optical Imaging and Microscopy of Vascular Compartment Dynamics During Somatosensory Stimulation", NeuroImage, 35(1): 89-104 (2007)

Detailed Technology Description

Laminar optical tomography (LOT) is a technique which allows non-contact depth-resolved optical imaging of living tissues to depths of >2 mm with 100-200 micron resolution. LOT allows the simultaneous quantification of absorption (and hence oxy- a...

Country/Region

USA

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