Potent inhibitors of human 9-cis retinol dehydrogenase

Lead Inventors: William Blaner Methods of detecting compounds that are capable of inhibiting the enzymatic activity of human 9-cis retinol dehydrogenase in in-vitro and in-vivo conditions are described. The compounds capable of inhibiting human 9-cis retinol dehydrogenase include naturally occurring and synthetic retinoids and lipids. A method for detecting a predisposition to cancer or a disease associated with either an over expression or under expression of a human 9-cis-retinol dehydrogenase is also proposed. Antisense oligonucleotides effective to prevent over expression of a human 9 cis-retinol dehydrogenase and are incorporated into pharmaceutical compositions along with a pharmaceutically acceptable carrier, are also described.The method provides important insights into the potent inhibitors of human 9-cis retinol dehydrogenase.

Methods of detecting compounds that are capable of inhibiting the enzymatic activity of human 9-cis retinol dehydrogenase in in-vitro and in-vivo conditions are described. The compounds capable of inhibiting human 9-cis retinol dehydrogenase in...

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