Chiral 1,8-Diarylnaphthalenes, Methods of Making Them, and Their Use as Sensors

An alternative to time consuming chromotagraphic analysisAbility to rapidly detect the enantioselectivity of in HTS of asymmetric reactionsIn situ detection allows for the screening of a compound’s stability to racemization.

Novel fluorescent molecular sensors can be used rapidly measure the enantiomeric excess of chiral chemical compounds without the need for time consuming chromatography techniques. Many biologically active compounds (flavors, nutrients, agrochemicals, pharmaceutical drugs) are chiral and used in enantiopure form. For example, while one enantiomer of a chiral drug can exhibit the desired pharmacological activity the other enantiomer can be toxic, so accurate measurements of enantio-purity are critical. These sensors utilize fluorescence and UV spectroscopy to allow the quantitative measurement of enantiopurity in chiral molecules. These sensors can be used for high-throughput synthetic screening (HTS) to rapidly detect the enantioselectivity of chemical reaction products and to determine a compound’s stability to racemization under different conditions.

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