Innovative Ebola Diagnostics

Apan-filovirus diagnostic can be developed that targets all six pathogenicstrains Recombinantfluorescent antibodies can be generated at very little cost compared toconventional monoclonal antibodiesIntrinsicfluorescence permits precise ratios determination of fluorescent signal toantibody-antigen interactions, therefore facilitating quantitative measurementsof target virusDoesnot require the extensive training and expensive equipment used in PCR-baseddiagnostic assaysUseof multiple fluorophores simultaneously would allow detection of multiplepathogensArapid method to generate new antibodies based on predicted epitope sequences ofescape filoviruses mutants Potentialfor rapid and inexpensive field-based diagnosis of filoviruses

Apanel of novel diagnostic antibodies for all six pathogenic filoviruses.

USA