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A Novel Treatment for Fragile X Synaptic and Cognitive Deficits


Detailed Technology Description

Fragile X syndrome (FX) is the most common form of inherited intellectual disability and occurs in roughly 1:3,600 males and 1:8,000 females. Based on a finding that mice with FX exhibit excessive vasculature in primary visual cortex, the Galvez Lab at the University of Illinois at Urbana-Champaign has significantly reduced both physical and cognitive abnormalities in affected mice by controlling the expression of vascular endothelial growth factor-A (VEGF-A), the dominant regulator of vascular growth.


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