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Selective Apoptotic Induction in Cancer Cells
Detailed Technology Description
PAC-1 and related compounds are small molecules capable of specifically killing cancer cells by inducing apoptosis. It does so by targeting an inactive apoptotic precursor, procaspase-3, that is up regulated in many cancer types. In vitro and in vivo studies have shown PAC-1 to be efficacious in reducing tumor cells at doses that show no toxicity in normal counterparts. This treatment could be used as a standalone cancer therapy or in combination with other chemotherapy drugs.
Countries
United States
Application No.
8778945
Country/Region
USA
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