Endothelial Mitogen-activated Protein Kinase Kinase Kinase Kinase (Map4k4) as a Therapeutic Target for Acute Imflammation, Vascular Permeability and Atherosclerosis
- Detailed Technology Description
- The technology provides novels compositions and methods for preventing formation of atherosclerotic plaques by administering inhibitory oligonucleotides, e.g. miRNA, that decrease Mitogen-activated pr
- Countries
- Not Available
- Application No.
- None
- *Abstract
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The technology provides novels compositions and methods for preventing formation of atherosclerotic plaques by administering inhibitory oligonucleotides, e.g. miRNA, that decrease Mitogen-activated protein kinase kinase kinase kinase 4 (Map4k4). This invention is based on the discovery that oligonucleotides that decrease the expression of Map4k4 mRNA in an endothelial cell reduce the induction of leukocyte adhesion molecules and reduce endothelial cell monolayer permeability. Further provided are methods of using oligonucleotides targeting Map4k4 therapeutic agents for atherosclerosis.
- *IP Issue Date
- None
- *IP Type
- Other Patent
- Country/Region
- USA
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