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Enzyme, Light and Catalytic Methods and Reagents for Inducing Bioorthgonal Reactivity

Detailed Technology Description

Bioorthogonal chemistry has evolved into afield with broad reaching applications in biology, medicine and materialsscience. The inverse-electron demand Diels-Alder reaction of s-tetrazineswith alkene or alkyne dienophiles, referred to as tetrazine ligation, is aprominent tool in the bioorthogonal toolbox. A notable aspect of the tetrazineligation are the exceptionally high rates of reactivity that can be achieved insimple biomolecular reactions.Scientists atthe University of Delaware have developed a new avenue for this reaction whereinbioorthogonal reactivity is turned on by a controllable, catalytic stimulus.Either visible light and a long wavelength sensitizer, or very low loadings ofhorseradish peroxidase are used to catalyze the oxidation of a dihydrotetrazineto a tetrazine. Thismethod can have broad applications in pretargeted drug delivery andphotodynamic therapy.

Countries

United States

Application No.

Patent Pending

Country/Region

USA

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