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Fluorescent Sensors of Tyrosine Phosphorylation
Detailed Technology Description
The invention is a novel means for the fluorescent detectionof tyrosine activity. A phosphotyrosine is used to mimic a glutamic acidresidue, Unlike previous methods, this approach combines a genetic encodabilitywith the exhibition of large fluorescence changes upon phosphorylation.Moreover, this approach is applicable to different kinases and phosphotasesthrough modification of the recognition sequence.
Countries
United States
Application No.
Patent Pending
Country/Region
USA
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