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Substrate for Protein Electron Microscopy with Reduced Non-Specific Binding

Summary

Researchers at Purdue University have developed a TEM grid for cryoEM with a coating that enables rapid and efficient capture of target proteins. The coatings limit non-specific adsorption and allow specific immobilization and random orientation of the protein target on the TEM grid. Capture of the target proteins in this manner controls their areal densities and efficiently limits film degradation. These TEM grids use smaller samples and accelerate sample preparation in comparison to available grids. These concepts can be extended to other coatings and films for TEM grids.

Technology Benefits

Accelerated sample preparation Smaller samples Binding in multiple orientations

Technology Application

Particle reconstruction analysis Further research and development High resolution cryoEM Structural biology

Detailed Technology Description

David ThompsonThompson GroupPurdue ChemistryPurdue Biomedical Engineering

Countries

United States

Application No.

N/A

Country/Region

USA

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