Synthesis and Applications of Trifluoroacetate
Researchers at Purdue University have developed a new synthetic reagent and method for the mild and efficient preparation of fluorinated compounds. This simple and straightforward method can be accomplished by a novice chemist, at room temperature, in open air, and without the need for complicated inert atmosphere techniques. Among other intermediates, Purdue researchers validated this method through its use in the aldol and imino-aldol processes, the facile production of difluoroenolates, and the formation of alpha, alpha-difluorinated beta amino acids. Difluorinated molecules, such as beta amino acids, are important research tools and building blocks for drug discovery.
Novel trifluoroacetate release strategy uses mild conditions (room temperature)Generation of pharmaceutically important intermediates Compatible with large scope of substrates
Chemical AnalysisMedical/HealthcarePharmaceuticalsDrug Development
Colby GroupPurdue Chemistry
United States
None
USA
