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Radionuclidic and Non-radionuclidic Molecular Imaging Agents for the Estrogen Receptor Based on 11-beta Subsituted Steroidal Anti-Estrogens

Technology Benefits

The technique:ΓÇóUtilizes novel steroidal derivatives as imaging agentsΓÇóAllows for an easier separation of unlabelled precursorsΓÇóIs based on high affinity anti-estrogen structure as compared to current estrogenic materialsΓÇóAllows for use of more stable and high affinity agents as compared to conventional techniquesΓÇóComprising the use of 11-beta substituted steroidal anti-estrogens as probes for ER selectivity and affinityΓÇóAllows for an easier detection of lesions in breast, ovaries, and uterus as compared to conventional techniquesΓÇóFurther allows for a reduced metabolism of agents as compared to conventional techniquesΓÇóIs modular in nature, comprising independent preparation of various components followed by incorporation using simple chemistries and physic-chemical diversitiesΓÇóWould be commercially useful for variety of applications such as PET, SPECT, Fluorescence, MRI and Raman especially for imaging at a cell, tissue, and a whole animal scale

Detailed Technology Description

None

Country/Region

USA

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