AsiaIPEX is a one-stop-shop for players in the IP industry, facilitating IP trade and connection to the IP world. Whether you are a patent owner interested in selling your IP, or a manufacturer looking to buy technologies to upgrade your operation, you will find the portal a useful resource.

Back to search results

Neuroprotective Compounds to Treat ParkinsonΓÇÖs Disease

Technology Benefits

- Orally bioavailable- Crosses the blood-brain barrier- Efficacy data in 3 animal models for ParkinsonΓÇÖs Disease- Accumulates in the substantia nigra and striatum within 1 hour, and persists for at least 24 hours- Protects dopaminergic neurons in vivo- Improved motor coordination (pole test, Rotor-Rod) and hyposmia (scent test)- No apparent long-term (12 months) side-effects or toxicity at therapeutically effective doses in a mouse model for PDIssued patents with broad composition of matter claims for Mito-apocynins and multiple derivative compounds, and method claims to:- Increase dopamine or dopac in the brain- Prevent a decrease in brain dopamine levels in Parkinson's disease- Reduce brain inflammation and/or neurotransmitter deficits- Delay neurodegeneration or lessen the effect of disease symptoms- Prolong motor function in a mammal with a neurodegenerative disease

Detailed Technology Description

Please view the complete technology summary and additional publications at "Technology page URL"

Country/Region

USA

For more information, please click Here