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Flagellin-Based Vaccine Adjuvants
Detailed Technology Description
Flagellin may be delivered as a purified protein for its adjuvant effect.Alternatively flagellin can be delivered as flagellin-expressing cells, which continuously release flagellin for a period of time.Flagellin can be expressed by tumor-antigen presenting cells that are lethally irradiated, hence localizing and prolonging the T-cell activation effect for tumor antigens.Flagellin adjuvants may enhance therapeutic tumor vaccine efficacy for many tumor types, including leukemia and melanoma.
Country/Region
USA

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