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Sarcoma miRNA Expression Database for Cancer Treatment

Technology Benefits

MiRNAs were discovered relatively recently and their functions are still being studied. Our lab is the first to study miRNAs in sarcomas using cutting edge ultra high throughput detection procedures. The data in this Sarcoma miRNA Expression Database is not available through any other researchers or organizations across the globe. It would be extremely difficult for researchers to independently assemble the tumors in this dataset due to their rarity. The Sarcoma MiRNA Expression Database allows users to define the miRNA types or relationships they are interested in studying, instead of being limited by previously analyzed data. This is the first database that allows users across the globe to search and view microRNA expression levels in different sarcomas through a web interface.

Technology Application

DNA microarray studies have identified differentially expressed genes in various sarcomas. Many of these genes are regulated by miRNAs. MiRNAs are non-coding regulatory small RNAs that display tissue and stage specific expression. By accelerating the understanding and identification of miRNAs in sarcomas, the Sarcoma miRNA Expression Database facilitates the development of miRNA-based cancer biomarkers for different sarcoma subtypes. These miRNAs can also be used to differentiate the stages of the tumors (i.e., primary or metastatic) and the origin of the metastatic tumors. The database facilitates the diagnosis, prognosis and treatment of different types of sarcomas, for which very few diagnostic markers currently exist.

Detailed Technology Description

None

Country/Region

USA

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