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Inhibition of Retinoic Acid Production for HIV Vaccination
Technology Benefits
- A vaccine strategy that circumvents the problem of induction of HIV-1 virus infection targets by current HIV vaccine candidates.- In vivo blockade of ALDH1a2 not only augments anti-HIV vaginal mucosal immunity, the most critical defense layer, but also enhances anti-HIV systemic immune responses.- Silencing ALDH1a2 in human DCs inhibits the expression of ß7 on activated CD4+ T cells, demonstrating strong clinical relevance.
Detailed Technology Description
Publications:An effective vaccination approach augments anti-HIV systemic and vaginal immunity in mice with decreased HIV-1 susceptible a4ß7high CD4+ T cells. Zhu W, Shi G, Tang H, Lewis DE, Song XT. Curr HIV Res. 2013 Jan;11(1):56-66.
Country/Region
USA
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