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Retargeting of Helper-Dependent Adenovirus by Modification of the Fiber with Metabolic Biotinylation
Technology Benefits
1) Efficient in vitro and in vivo targeting of different cell types and tissues depending only availability of monoclonal antibody to cell type surface protein2) Ability to utilize HD-Ad system to delivery up to 36 kb of transgenic DNA3) Low immunogenicity of HD-Ad because of absence of Adenovirus proteins4) Detargeting from natural Adenovirus target tissues and cells that depend on Coxackie Adenovirus Receptor (CAR) uptake
Detailed Technology Description
None
Country/Region
USA
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