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MicroRNAs sensitize ovarian cancers to platinum chemotherapy

Technology Benefits

- MicroRNAs miR-520-a, g, and/or h dramatically sensitize ovarian cancers to platinum-based chemotherapy. Thus, synthetic mimics for miR-520h can be used to increase the potency of platinum-based agents, while reducing the incidence of side effects and dramatically improving outcomes.- The present invention is useful and effective for treating a wide range of other cancers, given the central role that platinum-based agents play in standard of care treatment for other human cancers,- The compositions of the invention are unique in that they target multiple gene products across different signaling pathways involved in platinum resistance.- The reagents used to synthesize these liposomes can allow for the cost effective, readily scalable mass production of a clinical vector that can be incorporated into standard of care treatments for ovarian cancer.

Detailed Technology Description

None

Country/Region

USA

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