CONSERVED INFLUENZA VIRUS HEMAGGLUTININ EPITOPE, ANTIBODIES TO THE EPITOPE, AND METHODS OF USE
Influenza virus
The described Influenza Hemagglutinin epitope can be used in vaccines, vaccine development, as a target for drug discovery and to elicit antibodies in vivo or identify antibodies or other binding proteins in vitro (such as in libraries) that can be used as therapeutic or diagnostic products.
Dana-Farber scientists discovered a novel and conserved epitope on the stem region of group 1 influenza viruses and described human broad-spectrum neutralizing antibodies that recognize this epitope.
Inventor: MARASCO, Wayne, A. | SUI, Jianhua | LIDDINGTON, Robert, C.
Priority Number: WO2010027818A3
IPC Current: C07K001610 | A61K0039145 | C07K001411 | G01N003350
Assignee Applicant: Dana-Farber Cancer Institute Inc. | Burnham Institute for Medical Research
Title: CONSERVED HEMAGGLUTININ EPITOPE, ANTIBODIES TO THE EPITOPE, AND METHODS OF USE | EPITOPE CONSERVÉ D'HÉMAGGLUTININE, ANTICORPS CONTRE L'ÉPITOPE ET PROCÉDÉS D'UTILISATION
Usefulness: CONSERVED HEMAGGLUTININ EPITOPE, ANTIBODIES TO THE EPITOPE, AND METHODS OF USE | EPITOPE CONSERVÉ D'HÉMAGGLUTININE, ANTICORPS CONTRE L'ÉPITOPE ET PROCÉDÉS D'UTILISATION
Summary: The immunogen and methods are useful for preventing disease or disorder caused by influenza virus; treating subject, where the subject produces an immune response that prevents or reduces the severity of an influenza infection, and where the immune response is reactive to influenza viruses within a subtype, the immune response is reactive to influenza viruses in each subtype within a cluster, the immune response is reactive to influenza viruses in each cluster within a group, the immune response is reactive to all influenza viruses in each subtype within a group, or the immune response is reactive to influenza viruses within group 1; and for screening compound for binding to F10 antibody (all claimed).
Novelty: New immunogen comprises epitope or epitope unit recognized by protective monoclonal antibody having specificity for stem region of hemagglutinin protein of influenza virus, used for preventing disease or disorder caused by influenza virus
Biomedical
Pathogen
USA
