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A-17 Archaeal Proteasome to Digest Human Aggregating Proteins

Technology Benefits

ΓùÅ Simple: Archaeal proteasome only has one pair of ╬▒, ╬▓ subunits while human has 7 different ╬▒, ╬▓ subunitsΓùÅ Higher activity: Archaeal proteasome has much higher activity in digesting polyglutamine chains compared to human proteasomesΓùÅ Specific: This proteasome digests only aggregating proteins related to neuronal disorders

Technology Application

ΓùÅ Therapeutic Medicine for Neuronal Disorders (ParkinsonΓÇÖs, ALS, Polyglutamine, AlzheimerΓÇÖs Diseases)ΓùÅ Preventive MedicineΓùÅ Research Tool

Detailed Technology Description

None

Supplementary Information

Inventor: Ramesh, Narayanaswamy | Anton, Ines M. | Hartwig, John H. | Geha, Raif S.
Priority Number: US6635446B1
IPC Current: C07K001447 | C12N001512
US Class: 4350691 | 4352523 | 4353201 | 435325 | 530395 | 5360235
Assignee Applicant: The Children's Medical Center Corporation,Boston
Title: WIP, a WASP-associated protein
Usefulness: WIP, a WASP-associated protein
Summary: WIP or DNA encoding WIP can be administered to an individual, in sufficient quantity to alter actin content and/or the extent to which polymerization occurs, and thus, to prevent or reduce (totally or partially) cytoskeletal abnormalities and other adverse effects. In particular, Wiskott-Aldrich syndrome can be treated or prevented in this manner.

Industry

Biomedical

Sub Group

Medical Composition

Country/Region

USA

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